Corneal Biomechanical Parameters and Central Corneal Thickness in Glaucoma Patients, Glaucoma Suspects, and a Healthy Population

Purpose: To evaluate and compare corneal hysteresis (CH), resistance factor (CRF), central thickness (CCT), measurements were taken between a healthy population (controls), patients diagnosed with glaucoma (DG), suspect due to ocular hypertension (OHT), family history of (FHG), or glaucoma-like optic discs (GLD). Additionally, Goldmann-correlated intraocular pressure (IOPg) corneal-compensated IOP (IOPcc) compared the different groups patients. Methods: In this prospective analytical-observational study, total 1065 (one eye each) recruited undergo Ocular Response Analyzer (ORA) testing, ultrasound pachymetry, clinical examination. Corneal biomechanical parameters (CH, CRF), CCT, IOPg, IOPcc measured in control group (n = 574) other groups: DG 147), FHG 78), GLD 90), OHT 176). We performed variance analysis (ANOVA) for all dependent variables according diagnostic categories multiple comparisons identify differences categories, deeming p < 0.05 as statistically significant. Results: The mean CH (9.69 mmHg) was significantly lower controls (10.75 mmHg; difference 1.05, 0.001), (10.70 1.00, 0.05), (10.63 0.93, 0.05) (10.54 0.84, 0.05). No suspects (FHG, GLD, groups) presented significant themselves (p 1.00). found CRF (11.18 0.42, 0.40). showed higher values (12.32 12.41 mmHg, respectively) than mmHg), 1.13 1.22 respectively. CCT (562 ?) (control 556 ?, 576 569 570 ?). means IOPg patient group, 0.001). Conclusion: This study presents patients, three suspected groups, population, using ORA. Mean markedly (diagnosed damage) groups. Unexpectedly, but only OHT), not group.